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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SYN1 All Species: 9.39
Human Site: T448 Identified Species: 25.83
UniProt: P17600 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17600 NP_008881.2 705 74111 T448 A L P L G R Q T S Q Q P A G P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001086745 582 63133 I369 E M F G G L D I C A V K A V H
Dog Lupus familis XP_538411 578 63013 V365 G R D Y I I E V M D S S M P L
Cat Felis silvestris
Mouse Mus musculus O88935 706 74079 T448 A L T L G R Q T S Q Q P A G P
Rat Rattus norvegicus P09951 704 73970 T446 A L P L G R Q T S Q Q P A G P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510384 582 63180 V369 Y I I E M V S V K C F L C A G
Chicken Gallus gallus
Frog Xenopus laevis NP_001087750 655 71582 T413 L N R P T H G T Q P Q A Q V V
Zebra Danio Brachydanio rerio NP_001119909 670 72335 G434 Q R P P P Q G G P Q Q A A A S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24546 1025 107509 P453 Q T G P G K L P S R S S V S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 56.5 53 N.A. 96.1 96.1 N.A. 51 N.A. 60.9 61.8 N.A. 28.8 N.A. N.A. N.A.
Protein Similarity: 100 N.A. 66.5 64.6 N.A. 97 96.8 N.A. 63.1 N.A. 68.5 70.9 N.A. 41.3 N.A. N.A. N.A.
P-Site Identity: 100 N.A. 13.3 0 N.A. 93.3 100 N.A. 0 N.A. 13.3 26.6 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 20 6.6 N.A. 93.3 100 N.A. 6.6 N.A. 13.3 33.3 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 34 0 0 0 0 0 0 0 0 12 0 23 56 23 0 % A
% Cys: 0 0 0 0 0 0 0 0 12 12 0 0 12 0 0 % C
% Asp: 0 0 12 0 0 0 12 0 0 12 0 0 0 0 0 % D
% Glu: 12 0 0 12 0 0 12 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 12 0 0 0 0 0 0 0 12 0 0 0 0 % F
% Gly: 12 0 12 12 56 0 23 12 0 0 0 0 0 34 12 % G
% His: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 12 % H
% Ile: 0 12 12 0 12 12 0 12 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 12 0 0 12 0 0 12 0 0 0 % K
% Leu: 12 34 0 34 0 12 12 0 0 0 0 12 0 0 12 % L
% Met: 0 12 0 0 12 0 0 0 12 0 0 0 12 0 0 % M
% Asn: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 34 34 12 0 0 12 12 12 0 34 0 12 34 % P
% Gln: 23 0 0 0 0 12 34 0 12 45 56 0 12 0 0 % Q
% Arg: 0 23 12 0 0 34 0 0 0 12 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 12 0 45 0 23 23 0 12 23 % S
% Thr: 0 12 12 0 12 0 0 45 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 12 0 23 0 0 12 0 12 23 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 12 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _